A detailed understanding of the Ebola virus (EBOV) pathogenesis has not been possible because of safety concerns, which arise while handling the live EBOV. Understanding the mechanisms involved in EBOV entry, replication and inhibition of the antiviral response in the host cell are crucial for the development of effective therapeutic measures. In this article, we provide a description of the EBOV genome and the role of each EBOV protein in spreading infection in the host cell. We also discuss some of the major computational works done on EBOV for the purpose of developing effective vaccines and drugs. In addition, we list the known host proteins with which EBOV proteins interact to enter and spread infection in the host and also estimate their semantic similarity (SS) scores to test the efficiency of SS metric for the prediction of novel EBOV-human protein interactions.