Prognostic Factors of Human Immunodeficiency Virus-Infected Patients on Chronic Hemodialysis

Blood Purif. 2017;44(3):244-250. doi: 10.1159/000478966. Epub 2017 Oct 3.

Abstract

Background/aims: The number of human immunodeficiency virus (HIV)-infected patients on hemodialysis (HD) have increased, and their prognostic factors are still poorly clarified. The study aimed to identify factors that can influence the survival of HIV-infected patients on HD.

Methods: We performed a retrospective cohort study of 44 HIV-infected patients on HD.

Results: A total of 17 patients (39%) died. Median survival on HD was 30.8 months and the survival rate at 1 and 5 years was 82.5 and 62.9%, respectively. Male (relative risk [RR] 3.1, p = 0.040) and blacks (RR 2.5, p = 0.037) had higher risk of death. The patients who died had a shorter duration of HIV infection (p = 0.028), had a higher viral load (p = 0.044), more opportunistic infections (p = 0.013), and a lower serum albumin (p = 0.009). Lower serum albumin, nonsexual HIV transmission, viral load, opportunistic infections, and usage of catheters were associated with lower survival.

Conclusion: Several demographic, viral, and dialysis variables may help to predict survival of this population. The intervention in these factors could improve their prognosis.

Keywords: Hemodialysis; Human immunodeficiency virus infection; Survival.

MeSH terms

  • Adult
  • Aged
  • Disease-Free Survival
  • Female
  • Follow-Up Studies
  • HIV Infections / mortality*
  • HIV Infections / therapy*
  • HIV-1*
  • Humans
  • Male
  • Middle Aged
  • Renal Dialysis*
  • Retrospective Studies
  • Sex Factors
  • Survival Rate