Increased risk of chronic kidney disease in patients with rosacea: A nationwide population-based matched cohort study

Hsien-Yi Chiu; Wen-Yen Huang; Chung-Han Ho; Jhi-Joung Wang; Sung-Jan Lin; Ya-Wen Hsu; Ping-Jen Chen

doi:10.1371/journal.pone.0180446

Increased risk of chronic kidney disease in patients with rosacea: A nationwide population-based matched cohort study

PLoS One. 2017 Oct 2;12(10):e0180446. doi: 10.1371/journal.pone.0180446. eCollection 2017.

Authors

Hsien-Yi Chiu^{1

2

3}, Wen-Yen Huang¹, Chung-Han Ho^{4

5

6}, Jhi-Joung Wang⁴, Sung-Jan Lin^{1

3

7}, Ya-Wen Hsu^{4

5}, Ping-Jen Chen^{8

9}

Affiliations

¹ Institute of Biomedical Engineering, College of Medicine and College of Engineering, National Taiwan University, Taipei, Taiwan.
² Department of Dermatology, National Taiwan University Hospital Hsin-Chu Branch, Hsinchu, Taiwan.
³ Department of Dermatology, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan.
⁴ Department of Medical Research, Chi Mei Medical Center, Tainan, Taiwan.
⁵ Department of Hospital and Health Care Administration, Chia Nan University of Pharmacy and Science, Tainan, Taiwan.
⁶ Department of Pharmacy, Chia Nan University of Pharmacy and Science, Tainan, Taiwan.
⁷ Research Center for Developmental Biology and Regenerative Medicine, National Taiwan University, Taipei, Taiwan.
⁸ Department of Geriatrics and Gerontology, Chi-Mei Medical Center, Tainan, Taiwan.
⁹ Department of Family Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan.

Abstract

Background: Rosacea is a chronic inflammatory skin disorder. Inflammation and oxidative stress are involved in the etiopathogenesis of rosacea and chronic kidney disease (CKD). This study aimed to investigate the association between rosacea and CKD.

Methods: This population-based cohort study identified 277 patients with rosacea in the Taiwan National Health Insurance Research Database during 2001-2005. These patients were matched for age, sex, and comorbidities with 2216 patients without rosacea. All subjects were individually followed-up for 8-12 years to identify those who subsequently developed CKD.

Results: The incidence rates of CKD per 1000 person-years were 16.02 in patients with rosacea and 10.63 in the non-rosacea reference population. After adjusting for other covariates and considering the competing risk of mortality, patients with rosacea remained at increased risk of CKD (adjusted sub-distribution hazard ratio (aSD-HR) 2.00; 95% confidence interval (CI) 1.05-3.82). The aSD-HRs (95% CI) for CKD were 1.82 (0.83-4.00) and 2.53 (1.11-5.75) for patients with mild and moderate-to-severe rosacea, respectively.

Conclusions: Rosacea is an independent risk factor for CKD. High rosacea severity and old age further increased CKD risk in patients with rosacea. Careful monitoring for CKD development should be included as part of integrated care for patients with rosacea.

MeSH terms

Adolescent
Adult
Female
Humans
Kidney Failure, Chronic / complications*
Male
Middle Aged
Population Surveillance*
Retrospective Studies
Risk Factors
Rosacea / complications*
Young Adult

Grants and funding

This work was supported in part by a grant from the National Taiwan University Hospital Hsin-Chu Branch (106-HCH002). The funder had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. There was no additional external funding received for this study.