Abstract
We report the case of a 61 year-old male who underwent heart transplantation eight months before developing a systemic condition with central nervous system, lung, kidney, colonic, cutaneous, and hematologic involvement, found to be secondary to a systemic toxoplasmosis despite co-trimoxazole prophylaxis in a previous-to-transplant seronegative patient receiving a heart from a seropositive donor. A review of prophylactic options in our environment is discussed.
Keywords:
Toxoplasmosis; heart transplantation; immune tolerance; seroconversion.
MeSH terms
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Antibodies, Protozoan / blood
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Antiviral Agents / therapeutic use
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Combined Modality Therapy
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Cytomegalovirus Infections / drug therapy
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Cytomegalovirus Infections / transmission
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Disease Progression
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Heart Transplantation*
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Humans
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Immunoglobulins, Intravenous / therapeutic use
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Immunosuppressive Agents / adverse effects
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Male
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Middle Aged
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Plasma Exchange
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Postoperative Complications / etiology*
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Postoperative Complications / parasitology
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Postoperative Complications / prevention & control
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Recurrence
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Seroconversion
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Tissue Donors
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Toxoplasmosis / prevention & control
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Toxoplasmosis / transmission*
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Trimethoprim, Sulfamethoxazole Drug Combination / administration & dosage
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Viremia / drug therapy
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Viremia / transmission
Substances
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Antibodies, Protozoan
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Antiviral Agents
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Immunoglobulins, Intravenous
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Immunosuppressive Agents
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Trimethoprim, Sulfamethoxazole Drug Combination