Disseminated toxoplasmosis in a heart transplant patient despite co-trimoxazole prophylaxis: A case report

Biomedica. 2017 Sep 1;37(3):303-307. doi: 10.7705/biomedica.v37i3.3189.

Abstract

We report the case of a 61 year-old male who underwent heart transplantation eight months before developing a systemic condition with central nervous system, lung, kidney, colonic, cutaneous, and hematologic involvement, found to be secondary to a systemic toxoplasmosis despite co-trimoxazole prophylaxis in a previous-to-transplant seronegative patient receiving a heart from a seropositive donor. A review of prophylactic options in our environment is discussed.

Keywords: Toxoplasmosis; heart transplantation; immune tolerance; seroconversion.

Publication types

  • Case Reports

MeSH terms

  • Antibodies, Protozoan / blood
  • Antiviral Agents / therapeutic use
  • Combined Modality Therapy
  • Cytomegalovirus Infections / drug therapy
  • Cytomegalovirus Infections / transmission
  • Disease Progression
  • Heart Transplantation*
  • Humans
  • Immunoglobulins, Intravenous / therapeutic use
  • Immunosuppressive Agents / adverse effects
  • Male
  • Middle Aged
  • Plasma Exchange
  • Postoperative Complications / etiology*
  • Postoperative Complications / parasitology
  • Postoperative Complications / prevention & control
  • Recurrence
  • Seroconversion
  • Tissue Donors
  • Toxoplasmosis / prevention & control
  • Toxoplasmosis / transmission*
  • Trimethoprim, Sulfamethoxazole Drug Combination / administration & dosage
  • Viremia / drug therapy
  • Viremia / transmission

Substances

  • Antibodies, Protozoan
  • Antiviral Agents
  • Immunoglobulins, Intravenous
  • Immunosuppressive Agents
  • Trimethoprim, Sulfamethoxazole Drug Combination