A Tale of Two Elabela Null Mice

Trends Endocrinol Metab. 2017 Nov;28(11):759-760. doi: 10.1016/j.tem.2017.09.004. Epub 2017 Sep 27.

Abstract

Elabela (ELA), the second peptide ligand for the apelin receptor, APLNR, was previously found in lower vertebrates to be crucial for endoderm and cardiac development. Two new studies report on the phenotypes of Ela null mice, ranging from defective embryogenesis to preeclampsia, providing new insights and raising greater intrigue on this cardiometabolic pathway.

Keywords: APLNR signaling; GPCR; embryo development; preeclampsia.

Publication types

  • Comment

MeSH terms

  • Animals
  • Apelin Receptors
  • Female
  • Humans
  • Mice
  • Mice, Knockout
  • Penetrance*
  • Peptide Hormones / genetics
  • Pre-Eclampsia*
  • Pregnancy

Substances

  • APLNR protein, human
  • Apelin Receptors
  • Peptide Hormones