Beta-glucans and cancer: The influence of inflammation and gut peptide

Eur J Med Chem. 2017 Dec 15:142:486-492. doi: 10.1016/j.ejmech.2017.09.013. Epub 2017 Sep 15.

Abstract

Dietary β-glucans are soluble fibers with potentially health-promoting effects. Gut peptides are important signals in the regulation of energy and glucose homeostasis. This article reviews the effects of different enriched β-glucan food consumption on immune responses, inflammation, gut hormone and cancer. Gut hormones are influenced by enriched β-glucan food consumption and levels of such peptide as YY, ghrelin, glucagon-like peptide 1 and 2 in humans influence serum glucose concentration as well as innate and adaptive immunity. Cancer cell development is also regulated by obesity and glucose dishomeostasy that are influenced by β-glucan food consumption that in turn regulated gut hormones.

Keywords: Cancer; GLP-1; GLP-2; Ghrelin; Glucose; Inflammation; Insulin; PYY; β-Glucans.

Publication types

  • Review

MeSH terms

  • Animals
  • Functional Food* / analysis
  • Ghrelin / immunology
  • Ghrelin / metabolism
  • Glucagon-Like Peptide 1 / immunology
  • Glucagon-Like Peptide 1 / metabolism
  • Glucagon-Like Peptide 2 / immunology
  • Glucagon-Like Peptide 2 / metabolism
  • Humans
  • Inflammation / immunology
  • Inflammation / metabolism
  • Inflammation / therapy*
  • Neoplasms / immunology
  • Neoplasms / metabolism
  • Neoplasms / therapy*
  • Peptide YY / immunology
  • Peptide YY / metabolism
  • beta-Glucans / analysis
  • beta-Glucans / pharmacology
  • beta-Glucans / therapeutic use*

Substances

  • Ghrelin
  • Glucagon-Like Peptide 2
  • beta-Glucans
  • Peptide YY
  • Glucagon-Like Peptide 1