A three-miRNA-based expression signature at diagnosis can predict occurrence of relapse in children with t(8;21) RUNX1-RUNX1T1 acute myeloid leukaemia

Br J Haematol. 2018 Oct;183(2):298-301. doi: 10.1111/bjh.14950. Epub 2017 Sep 29.
No abstract available

Keywords: miRNA; miRNA signature; paediatric AML; relapse; t(8;21)RUNX1-RUNX1T1.

Publication types

  • Multicenter Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Child
  • Child, Preschool
  • Chromosomes, Human, Pair 21 / genetics*
  • Chromosomes, Human, Pair 8 / genetics*
  • Female
  • Gene Expression Profiling / methods
  • Humans
  • Infant
  • Infant, Newborn
  • Leukemia, Myeloid, Acute / genetics*
  • Leukemia, Myeloid, Acute / therapy
  • Male
  • MicroRNAs / genetics
  • Prognosis
  • RNA, Neoplasm / genetics
  • RUNX1 Translocation Partner 1 Protein / genetics*
  • Recurrence
  • Retrospective Studies
  • Translocation, Genetic*

Substances

  • MicroRNAs
  • RNA, Neoplasm
  • RUNX1 Translocation Partner 1 Protein
  • RUNX1T1 protein, human