A Bench-Stable, Single-Component Precatalyst for Silyl-Heck Reactions

Sarah B Krause; Jesse R McAtee; Glenn P A Yap; Donald A Watson

doi:10.1021/acs.orglett.7b02807

A Bench-Stable, Single-Component Precatalyst for Silyl-Heck Reactions

Org Lett. 2017 Oct 20;19(20):5641-5644. doi: 10.1021/acs.orglett.7b02807. Epub 2017 Sep 29.

Authors

Sarah B Krause¹, Jesse R McAtee¹, Glenn P A Yap¹, Donald A Watson¹

Affiliation

¹ Department of Chemistry and Biochemistry, University of Delaware , Newark, Delaware 19716, United States.

Abstract

Studies of the silyl-Heck reaction aimed at identifying active palladium complexes have revealed a new species that is formed in situ. This complex has been identified as the palladium iodide dimer, [(JessePhos)PdI₂]₂, which has been found to be a competent single-component precatalyst for the silyl-Heck reaction. This complex is easily prepared and is temperature, moisture, and air stable. Additionally, this precatalyst provides higher activity and greater reproducibility compared to previous systems.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

Catalysis*
Molecular Structure
Palladium
Reproducibility of Results

Substances

Palladium

Abstract

Publication types

MeSH terms

Substances

Grants and funding