Abstract
Aspergillus myofasciitis is a rare infection of the muscles and their fascial sheaths that has been reported in patients with immune deficiencies of various kinds but, until now, not with chronic granulomatous disease (CGD). Patients affected by CGD are at high risk of invasive aspergillus infections. The case described involves a 14-year-old boy with a severe autosomal recessive CGD who was admitted to hospital with an Aspergillus myofasciitis of the left forearm. He was treated with liposomal amphotericin for 14 days and then with oral voriconazole for three months with an excellent clinical outcome. He did not evidence any recurrence in the following 30 months using itraconazole prophylaxis.
MeSH terms
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Adolescent
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Amphotericin B / therapeutic use
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Antifungal Agents / therapeutic use
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Aspergillosis / drug therapy
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Aspergillosis / etiology*
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Aspergillosis / microbiology
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Aspergillosis / surgery
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Aspergillus fumigatus / isolation & purification*
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Combined Modality Therapy
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Debridement
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Drug Therapy, Combination
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Fasciitis / drug therapy
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Fasciitis / etiology*
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Fasciitis / microbiology
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Fasciitis / surgery
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Forearm
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Granulomatous Disease, Chronic / complications*
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Humans
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Interferon-gamma / therapeutic use
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Itraconazole / therapeutic use
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Male
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Pyomyositis / drug therapy
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Pyomyositis / etiology*
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Pyomyositis / microbiology
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Pyomyositis / surgery
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Trimethoprim, Sulfamethoxazole Drug Combination / therapeutic use
Substances
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Antifungal Agents
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liposomal amphotericin B
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Itraconazole
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Amphotericin B
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Trimethoprim, Sulfamethoxazole Drug Combination
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Interferon-gamma