Abstract
Serotonin syndrome (SS), a potentially life-threatening adverse drug reaction caused by excessive serotonergic agonism in central and peripheral nervous system serotonergic receptors, may be caused by a single drug or a combination of drugs with serotonergic activity. The syndrome results in a variety of mental, autonomic and neuromuscular changes, which can range in severity from mild to life-threatening. To our knowledge, we present the first reported case of SS associated with linezolid and methadone with a brief review of the literature.
MeSH terms
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Adult
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Anti-HIV Agents / therapeutic use
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Drug Synergism
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Drug Therapy, Combination
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HIV Infections / complications
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Humans
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Linezolid / administration & dosage
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Linezolid / adverse effects*
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Linezolid / pharmacokinetics
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Linezolid / therapeutic use
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Male
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Methadone / administration & dosage
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Methadone / adverse effects*
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Methadone / pharmacokinetics
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Methadone / therapeutic use
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Methicillin-Resistant Staphylococcus aureus / isolation & purification
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Monoamine Oxidase Inhibitors / adverse effects
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Monoamine Oxidase Inhibitors / pharmacokinetics
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Opiate Substitution Treatment
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Selective Serotonin Reuptake Inhibitors / adverse effects
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Selective Serotonin Reuptake Inhibitors / pharmacokinetics
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Serotonin Syndrome / etiology*
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Staphylococcal Infections / drug therapy
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Staphylococcal Infections / microbiology
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Substance Abuse, Intravenous / complications
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Substance Abuse, Intravenous / drug therapy
Substances
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Anti-HIV Agents
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Monoamine Oxidase Inhibitors
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Serotonin Uptake Inhibitors
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Linezolid
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Methadone