Biofilm associated Vibrio cholerae exhibits hypervirulence and supreme fitness against the harsh stresses during its infectious cycle. It is important to study the relationships between the regulation mechanism of V. cholerae biofilm development and its environmental adaption in host niche and aquatic habitat. Here, we summarize the recent advances in V. cholerae biofilm, including biofilm compositions, development and regulation. Particularly, we extensively discuss how V. cholerae fosters its biofilm architecture and assembly via sensing and responding various environmental determinants, such as bacterium self-produced molecules, natural environment components and host factors.
生物被膜状态的霍乱弧菌具有极强的环境适应性和超高的感染性，生物被膜的发育调控研究对霍乱弧菌的宿主感染和环境适应非常重要。本文综述了近年来霍乱弧菌生物被膜研究结果，包括霍乱弧菌生物被膜的组成、发育和环境调控，尤其着重阐述了各种环境因子对霍乱弧菌生物被膜发育的影响，包括细菌自体信号分子、自然环境因子和宿主信号分子。.
Keywords: Vibrio cholerae; biofilm; environmental determinants.