Biofilm is a bacterial lifestyle ubiquitously in natural environments. Bacterial biofilm leads to drug resistance, a main reason why many infectious diseases are difficult to control. Due to the prominent points of biofilms implicated in infectious disease and the spread of multi-drug resistance, it is urgent to discover new antibacterial agents that can regulate biofilm formation and development. This review introduces chemical agents that could modulate bacterial biofilm formation and development.
细菌的生物被膜是其在自然界中一种常见的生存状态。生物被膜的形成是细菌耐药性产生的主要机制之一，也是许多感染性疾病难以控制的重要原因。由于生物被膜在传染性疾病中的突出地位和细菌多重耐药性的蔓延，目前急需研制开发出能够调节生物被膜形成的新型抗菌药物。文中对调节生物被膜形成和发育的小分子抑制剂进行了详细的综述。.
Keywords: biofilm; dispersal; inhibit; natural products; signaling molecules; structure-activity relationship analysis.