Bacterial biofilm plays an important role in persistent microbial infection. Delineation of the formation and development of bacterial biofilm would provide a promising strategy to treat recalcitrant infection. c-di-AMP (Cyclic diadenosine monophosphate) is a recently identified second messenger of bacteria and involved in plethora of bacterial activities, including cell growth, cell wall homeostasis, biofilm formation and microbial pathogenicity. Here we review the recent literature pertinent to the role and molecular mechanisms of c-di-AMP in regulating biofilm formation of bacteria. The potential application of c-di-AMP and its related proteins in the development of novel antimicrobial therapeutics has also been discussed.
细菌生物被膜是细菌持续性致病的重要机制。研究细菌生物被膜的形成和发展可为顽固性细菌感染防治提供新的思路与策略。环二腺苷酸c-di-AMP (Cyclic diadenosine monophosphate) 是继c-di-GMP 之后在细菌中新发现的一种核苷酸第二信使分子。研究发现，c-di-AMP 参与调节细菌多种生理功能，包括细菌生长代谢、生物被膜形成、细胞壁的合成以及细菌毒力因子等。本文综述了c-di-AMP 参与调控细菌生物被膜形成的不同方式及其分子机制。鉴于c-di-AMP 在调控细菌生物被膜中的重要性，其可作为抗细菌生物被膜感染新药研发的潜在靶点。.
Keywords: bacteria; biofilm; c-di-AMP; c-di-GMP.