Evaluation of the Commercial Kit SIRE Nitratase for detecting resistant Mycobacterium tuberculosis in Brazil

Rev Soc Bras Med Trop. 2017 Jul-Aug;50(4):550-553. doi: 10.1590/0037-8682-0447-2016.

Abstract

Introduction:: This study aimed to evaluate a new commercial kit, Kit SIRE Nitratase-PlastLabor, for testing the drug susceptibility of clinical Mycobacterium tuberculosis isolates.

Methods:: The accuracy of the Kit SIRE Nitratase was evaluated by examining the susceptibility (streptomycin, isoniazid, rifampicin, and ethambutol) of 40 M. tuberculosis isolates, using the proportion method with Lowenstein-Jensen medium or the BACTEC MGIT 960 system.

Results:: The detection accuracy for streptomycin, isoniazid, rifampicin, and ethambutol was 95%, 97.5%, 100%, and 80%, respectively.

Conclusions:: The exceptional accuracy demonstrated by Kit SIRE Nitratase for isoniazid and rifampicin makes the kit an attractive option for screening M. tuberculosis strain resistance.

MeSH terms

  • Antibiotics, Antitubercular / pharmacology*
  • Clinical Enzyme Tests / methods
  • Drug Resistance, Bacterial
  • Ethambutol / pharmacology
  • Humans
  • Isoniazid / pharmacology
  • Microbial Sensitivity Tests / methods*
  • Mycobacterium tuberculosis / drug effects*
  • Mycobacterium tuberculosis / isolation & purification
  • Oxidoreductases / pharmacology*
  • Reproducibility of Results
  • Rifampin / pharmacology
  • Streptomycin / pharmacology

Substances

  • Antibiotics, Antitubercular
  • Ethambutol
  • Oxidoreductases
  • nitratase
  • Isoniazid
  • Rifampin
  • Streptomycin