A new selaginellin derivative and a new triarylbenzophenone analog from the whole plant of Selaginella pulvinata

J Asian Nat Prod Res. 2018 Dec;20(12):1123-1128. doi: 10.1080/10286020.2017.1378646. Epub 2017 Sep 27.

Abstract

Five selaginellin derivatives (1 and 3-6) including a new one, selaginellin T (1), and a new triarylbenzophenone analog, selagibenzophenone A (2), were isolated from the whole plants of Selaginella pulvinata. Their structures were determined by 1D- and 2D-NMR and HR-ESI-MS data. Selagibenzophenone A (2) is the first example of naturally occurring triarylbenzophenone. The results of the phosphodiesterase-4 (PDE4) inhibitory screening assays showed that compounds 1-6 exhibited potent activities with the IC50 values in the range of 1.04-9.35 μM.

Keywords: Selaginellaceae; phosphodiesterase-4; selaginellin derivative; triarylbenzophenone.

MeSH terms

  • Biphenyl Compounds / chemistry*
  • Biphenyl Compounds / pharmacology
  • Cyclohexanones / chemistry*
  • Cyclohexanones / pharmacology
  • Molecular Structure
  • Phosphodiesterase 4 Inhibitors / chemistry
  • Phosphodiesterase 4 Inhibitors / pharmacology
  • Selaginellaceae / chemistry*

Substances

  • Biphenyl Compounds
  • Cyclohexanones
  • Phosphodiesterase 4 Inhibitors