New 12,8-Eudesmanolides from Eutypella sp. 1-15

Yuezhou Wang; Yue Wang; An-An Wu; Lei Zhang; Zhiyu Hu; Huiying Huang; Qingyan Xu; Xianming Deng

doi:10.1038/ja.2017.89

New 12,8-Eudesmanolides from Eutypella sp. 1-15

J Antibiot (Tokyo). 2017 Oct;70(10):1029-1032. doi: 10.1038/ja.2017.89. Epub 2017 Jul 19.

Authors

Yuezhou Wang^{1

2}, Yue Wang^{1

2}, An-An Wu³, Lei Zhang^{1

2}, Zhiyu Hu^{1

2}, Huiying Huang^{1

2}, Qingyan Xu^{1

2}, Xianming Deng^{1

2}

Affiliations

¹ State Key Laboratory of Cellular Stress Biology, Innovation Center for Cell Signaling Network, School of Life Sciences, Xiamen University, Xiamen, China.
² State-province Joint Engineering Laboratory of Targeted Drugs from Natural Products, Xiamen University, Xiamen, China.
³ State Key Laboratory for Physical Chemistry of Solid Surface, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen, China.

PMID: 28951605
DOI: 10.1038/ja.2017.89

Abstract

Four new 12,8-Eudesmanolides (1-4) and one known compound 5 named 13-Hydroxy-3,7(11)-eudesmadien-12,8-olide, were isolated from a mangrove rhizosphere-derived fungus Eutypella sp. 1-15. Their structures with absolute stereochemistry were determined by the comprehensive spectroscopic data, experimental and calculated ECD analysis. Compound 1 exhibited potent anticancer activity against JEKO-1 and HepG2 with IC₅₀ values of 8.4 and 28.5 μM, respectively. Additionally, compound 1 also showed moderate antimicrobial activity.

MeSH terms

Anti-Infective Agents / chemistry
Anti-Infective Agents / isolation & purification
Anti-Infective Agents / pharmacology
Antineoplastic Agents / chemistry
Antineoplastic Agents / isolation & purification*
Antineoplastic Agents / pharmacology*
Cell Line, Tumor
Humans
Inhibitory Concentration 50
Rhizosphere
Sesquiterpenes / chemistry
Sesquiterpenes / isolation & purification*
Sesquiterpenes / pharmacology*
Soil Microbiology
Spectrum Analysis
Xylariales / chemistry*
Xylariales / isolation & purification

Substances

Anti-Infective Agents
Antineoplastic Agents
Sesquiterpenes
eudesmanolide