Functional polymer materials affecting cell attachment

Abstract

This review discusses the functional polymer materials effect on the cell adhesion. The applied polymer materials for the cell adhesion purpose was prepared based on organic fibers and biocompatible hydrogel. On the other hand, the active peptides are incorporated into the polymer materials substrate via the cysteine-containing peptides and N-hydroxysuccinimide-active group. Cancer cells and normal cells were presented for the selective adhesion via the introduced polymer materials substrate containing active peptides including Arginine-Glycine-Aspartic and Isoleucine-Lysine-Valine-Alanine-Valine sequence peptides. This selectivity is revealed by a significant cooperativity between specific and non-specific cell adhesion. This study is of a great impact for the design of the polymeric structures for cell attachment.

Keywords: Adhesion; Organic fibers; Polymer materials; Resins; Surface modification.