Morphological evaluation for diagnosis of dry eye related to meibomian gland dysfunction

Young-Sik Yoo; Kyung-Sun Na; Dae Yu Kim; Suk-Woo Yang; Choun-Ki Joo

doi:10.1016/j.exer.2017.07.005

Morphological evaluation for diagnosis of dry eye related to meibomian gland dysfunction

Exp Eye Res. 2017 Oct:163:72-77. doi: 10.1016/j.exer.2017.07.005.

Authors

Young-Sik Yoo¹, Kyung-Sun Na², Dae Yu Kim³, Suk-Woo Yang⁴, Choun-Ki Joo⁵

Affiliations

¹ Department of Convergence Medical Science, College of Medicine, The Catholic University of Korea, Seoul, South Korea; Catholic Institute for Visual Science, College of Medicine, The Catholic University of Korea, Seoul, South Korea.
² Department of Ophthalmology and Visual Science, College of Medicine, Yeouido St. Mary's Hospital, The Catholic University of Korea, Seoul, South Korea.
³ Electrical Engineering, College of Engineering, Inha University, Incheon, South Korea.
⁴ Department of Ophthalmology and Visual Science, College of Medicine, Seoul St. Mary's Hospital, The Catholic University of Korea, Seoul, South Korea.
⁵ Catholic Institute for Visual Science, College of Medicine, The Catholic University of Korea, Seoul, South Korea; Department of Ophthalmology and Visual Science, College of Medicine, Seoul St. Mary's Hospital, The Catholic University of Korea, Seoul, South Korea. Electronic address: ckjoo@catholic.ac.kr.

PMID: 28950940
DOI: 10.1016/j.exer.2017.07.005

Abstract

The evaluation of morphological changes of the acini in the meibomian glands is important for the diagnosis and management of dry eye related to meibomian gland dysfunction. While several tools have been developed to detect meibomian gland structure, infrared imaging is generally used in clinical settings. Unlike the lipid component analysis of tear film in which quantitative analysis is possible, the meibomian glands are limited to qualitative analysis because of the low image quality of the diagnostic tools. This review describes diagnostic tools, especially in terms of morphological evaluation of the acini, which are visualized by the existence of lipid within them.

Keywords: Dry eye disease; Meibomian glands; Optical coherence tomography.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Diagnostic Techniques, Ophthalmological*
Dry Eye Syndromes / pathology*
Humans
Meibomian Glands / pathology*
Microscopy / methods
Optical Imaging / methods
Tomography, Optical Coherence / methods