First total synthesis of a new phenylpropanoid glycoside: natural cytotoxic compound from Cirsium japonicum

J Asian Nat Prod Res. 2018 Dec;20(12):1154-1161. doi: 10.1080/10286020.2017.1379511. Epub 2017 Sep 26.

Abstract

Phenylpropanoid glycoside compound 1, the natural anti-tumor compound isolated from the erial parts of Cirsium japonicum, was first totally synthesized using easily available materials in short, convenient route with overall yield of 13.9%.

Keywords: Total synthesis; natural product; phenylpropanoid glycoside.

MeSH terms

  • Antineoplastic Agents, Phytogenic / chemical synthesis*
  • Antineoplastic Agents, Phytogenic / chemistry
  • Antineoplastic Agents, Phytogenic / pharmacology*
  • Cirsium / chemistry*
  • Glycosides / chemistry*
  • Glycosides / pharmacology*
  • Molecular Structure
  • Plant Extracts / chemistry

Substances

  • Antineoplastic Agents, Phytogenic
  • Glycosides
  • Plant Extracts