Changes in Sympathetic Innervation of the Heart in Rats with Experimental Myocardial Infarction. Effect of Semax

S A Gavrilova; M A Markov; A B Berdalin; A D Kurenkova; V B Koshelev

doi:10.1007/s10517-017-3862-3

Changes in Sympathetic Innervation of the Heart in Rats with Experimental Myocardial Infarction. Effect of Semax

Bull Exp Biol Med. 2017 Sep;163(5):617-619. doi: 10.1007/s10517-017-3862-3. Epub 2017 Sep 25.

Authors

S A Gavrilova¹, M A Markov¹, A B Berdalin², A D Kurenkova¹, V B Koshelev¹

Affiliations

¹ Department of Physiology and General Pathology, Faculty of Fundamental Medicine, M. V. Lomonosov Moscow State University, Moscow, Russia.
² Department of Physiology and General Pathology, Faculty of Fundamental Medicine, M. V. Lomonosov Moscow State University, Moscow, Russia. alex_berdalin@mail.ru.

PMID: 28948544
DOI: 10.1007/s10517-017-3862-3

Abstract

The effect of peptide Semax on remodeling of cardiac sympathetic innervation was examined in rats with experimental myocardial infarction. In 28 days after ischemia/reperfusion injury, Semax diminished the growth of sympathetic innervation of ventricular septum, although it produced no effect on the density of β₁ and β₂ adrenoceptors.

Keywords: Semax; autonomic nervous system; myocardial infarction.

MeSH terms

Adrenocorticotropic Hormone / analogs & derivatives
Adrenocorticotropic Hormone / therapeutic use
Animals
Male
Myocardial Infarction / drug therapy
Myocardial Infarction / metabolism*
Peptide Fragments / therapeutic use
Prostate / drug effects
Prostate / metabolism
Prostate / pathology
Prostatitis / drug therapy
Prostatitis / metabolism*
Quercetin / analogs & derivatives
Quercetin / therapeutic use
Rats
Rats, Wistar
Sympathetic Nervous System / drug effects
Sympathetic Nervous System / metabolism
Sympathetic Nervous System / pathology

Substances

Peptide Fragments
ACTH (4-7), Pro-Gly-Pro-
Adrenocorticotropic Hormone
Quercetin
taxifolin