Three New Triterpenoid Saponins from Notoginseng Medicinal Fungal Substance

Chem Biodivers. 2017 Dec;14(12). doi: 10.1002/cbdv.201700195. Epub 2017 Dec 1.

Abstract

Three new triterpenoid saponins, named ginsenoside-Rh23 (1), ginsenoside-Rh24 (2), and ginsenoside-Rh25 (3), were isolated from notoginseng medicinal fungal substance. Their structures were elucidated by a combination of 1D- and 2D-NMR, MS and chemical analysis. Compounds 1 - 3 exhibited moderate cytotoxic activity against MCF-7 and NCI-H460 cancer cell lines.

Keywords: Ginsenoside-Rh23; Ginsenoside-Rh24; Ginsenoside-Rh25; Notoginseng; Triterpenoid saponins.

MeSH terms

  • Cell Line, Tumor
  • Cell Survival / drug effects
  • Chromatography, Thin Layer
  • Ginsenosides / chemistry*
  • Ginsenosides / isolation & purification
  • Ginsenosides / toxicity
  • Humans
  • MCF-7 Cells
  • Magnetic Resonance Spectroscopy
  • Mass Spectrometry
  • Molecular Conformation
  • Panax / chemistry*
  • Panax / metabolism
  • Plant Roots / chemistry
  • Plant Roots / metabolism
  • Saponins / chemistry*
  • Saponins / toxicity
  • Triterpenes / chemistry*
  • Triterpenes / toxicity

Substances

  • Ginsenosides
  • Saponins
  • Triterpenes
  • ginsenoside-Rh23
  • ginsenoside-Rh24
  • ginsenoside-Rh25