Abstract
Three new triterpenoid saponins, named ginsenoside-Rh23 (1), ginsenoside-Rh24 (2), and ginsenoside-Rh25 (3), were isolated from notoginseng medicinal fungal substance. Their structures were elucidated by a combination of 1D- and 2D-NMR, MS and chemical analysis. Compounds 1 - 3 exhibited moderate cytotoxic activity against MCF-7 and NCI-H460 cancer cell lines.
Keywords:
Ginsenoside-Rh23; Ginsenoside-Rh24; Ginsenoside-Rh25; Notoginseng; Triterpenoid saponins.
© 2017 Wiley-VHCA AG, Zurich, Switzerland.
MeSH terms
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Cell Line, Tumor
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Cell Survival / drug effects
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Chromatography, Thin Layer
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Ginsenosides / chemistry*
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Ginsenosides / isolation & purification
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Ginsenosides / toxicity
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Humans
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MCF-7 Cells
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Magnetic Resonance Spectroscopy
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Mass Spectrometry
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Molecular Conformation
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Panax / chemistry*
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Panax / metabolism
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Plant Roots / chemistry
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Plant Roots / metabolism
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Saponins / chemistry*
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Saponins / toxicity
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Triterpenes / chemistry*
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Triterpenes / toxicity
Substances
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Ginsenosides
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Saponins
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Triterpenes
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ginsenoside-Rh23
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ginsenoside-Rh24
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ginsenoside-Rh25