Long non-coding and endogenous retroviral RNA levels are associated with proinflammatory cytokine mRNA expression in peripheral blood cells: Implications for schizophrenia

Psychiatry Res. 2018 Apr:262:465-468. doi: 10.1016/j.psychres.2017.09.025. Epub 2017 Sep 14.

Abstract

Recent research indicates that the expression of long non-coding and endogenous retroviral RNAs is coordinated with the activity of immune molecules often dysregulated in schizophrenia. We measured the expression of TMEVPG1, NRON, HERV-W env and HERV-W gag in blood cells from participants with schizophrenia and controls. We report that a) expression levels of these non-coding RNAs are correlated with proinflammatory cytokine mRNA expression in all participants, b) HERV-W transcripts are negatively correlated with atypical antipsychotic use in participants with schizophrenia, and c) that these RNAs are transcribed in response to proinflammatory stimuli in a THP-1 monocyte cell line.

Keywords: Cytokine; HERV-W; lncRNA.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Adult
  • Blood Cells / metabolism*
  • Cell Line
  • Cytokines / metabolism*
  • Female
  • Gene Products, env / metabolism*
  • Gene Products, gag / metabolism*
  • Humans
  • Inflammation* / blood
  • Inflammation* / genetics
  • Inflammation* / immunology
  • Male
  • Middle Aged
  • Pregnancy Proteins / metabolism*
  • RNA, Long Noncoding / metabolism*
  • Schizophrenia* / blood
  • Schizophrenia* / genetics
  • Schizophrenia* / immunology

Substances

  • Cytokines
  • Gene Products, env
  • Gene Products, gag
  • NRON long noncoding RNA, human
  • Pregnancy Proteins
  • RNA, Long Noncoding
  • syncytin