Tandem Biocatalysis Unlocks the Challenging de Novo Production of Plant Natural Products

Christophe Duplais; Yannick Estevez

doi:10.1002/cbic.201700508

Tandem Biocatalysis Unlocks the Challenging de Novo Production of Plant Natural Products

Chembiochem. 2017 Nov 16;18(22):2192-2195. doi: 10.1002/cbic.201700508. Epub 2017 Oct 27.

Authors

Christophe Duplais¹, Yannick Estevez¹

Affiliation

¹ CNRS, UMR8172 EcoFoG, AgroParisTech, Cirad, INRA, Université des Antilles, Université de Guyane, Campus agronomique avenue de France, 97379, Kourou, French Guiana, France.

PMID: 28940553
DOI: 10.1002/cbic.201700508

Abstract

Intimate partnership: Knowledge of the biocatalytic cascades in different cellular compartments is limited, but deciphering these systems in nature can be used to inspire synthetic strategies. Two studies report new insights into the biosynthesis of alkaloids and sesterterpenoids in plants. This highlight presents these novel biotransformations to illustrate how tandem biocatalysis can impact the future of natural product production.

Keywords: alkaloids; biosynthesis; enzyme catalysis; protein engineering; terpenes.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Biocatalysis*
Biological Products / chemistry
Biological Products / metabolism*
Plants / chemistry
Plants / metabolism*

Substances

Biological Products