Mechanisms of poststroke fatigue

J Neurol Neurosurg Psychiatry. 2018 Mar;89(3):287-293. doi: 10.1136/jnnp-2017-316007. Epub 2017 Sep 22.

Abstract

Poststroke fatigue is a debilitating symptom and is poorly understood. Here we summarise molecular, behavioural and neurophysiological changes related to poststroke fatigue and put forward potential theories for mechanistic understanding of poststroke fatigue.

Keywords: stroke.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Fatigue / etiology
  • Fatigue / metabolism
  • Fatigue / physiopathology*
  • Fatigue / psychology
  • Humans
  • Inflammation / metabolism
  • Kynurenine / metabolism
  • Signal Transduction
  • Stroke / complications
  • Stroke / metabolism
  • Stroke / physiopathology*
  • Stroke / psychology
  • Tryptophan / metabolism

Substances

  • Kynurenine
  • Tryptophan