RETRACTED: Inhibition of the TGF-β1/Smad signaling pathway protects against cartilage injury and osteoarthritis in a rat model

Life Sci. 2017 Nov 15:189:106-113. doi: 10.1016/j.lfs.2017.09.022. Epub 2017 Sep 20.

Abstract

This article has been retracted: please see Elsevier Policy on Article Withdrawal (https://www.elsevier.com/about/our-business/policies/article-withdrawal). This article has been retracted at the request of the Editor-in-Chief as there are concerns about the reliability of the results included in the article. The journal was initially contacted by several authors requesting retraction of this paper because these authors claimed that it was published without their knowledge and consent, although several authors have opposing opinions. Fig. 6A. contains similar parts of Fig 2C from another paper authored by the same group of authors published in Journal of Cellular Biochemistry, Volume 119, Issue 2, (2018) 1827-1840, https://doi.org/10.1002/jcb.26344, the journal requested the authors to provide the raw data. However, the authors were not able to fulfill this request.

Keywords: Cartilage injury; Osteoarthritis; Transforming growth factor-β1/Smad; TβRI inhibitor.

Publication types

  • Retracted Publication

MeSH terms

  • Animals
  • Arthritis, Experimental / genetics
  • Arthritis, Experimental / prevention & control*
  • Blotting, Western
  • Cartilage, Articular / injuries
  • Collagen Type X / genetics
  • Fluorescent Antibody Technique
  • Gene Expression Regulation / genetics
  • Osteoarthritis / genetics
  • Osteoarthritis / prevention & control*
  • Protein Serine-Threonine Kinases / genetics*
  • RNA, Messenger / metabolism
  • Rats
  • Rats, Inbred Lew
  • Receptor, Transforming Growth Factor-beta Type I
  • Receptors, Transforming Growth Factor beta / genetics*
  • Reverse Transcriptase Polymerase Chain Reaction
  • Signal Transduction / genetics
  • Smad2 Protein / genetics*
  • Smad3 Protein / genetics*

Substances

  • Collagen Type X
  • RNA, Messenger
  • Receptors, Transforming Growth Factor beta
  • Smad2 Protein
  • Smad2 protein, rat
  • Smad3 Protein
  • Smad3 protein, rat
  • Protein Serine-Threonine Kinases
  • Receptor, Transforming Growth Factor-beta Type I
  • Tgfbr1 protein, rat