Striatonigral direct pathway activation is sufficient to induce repetitive behaviors

Abstract

Pharmacological intervention in the substantia nigra is known to induce repetitive behaviors in rodents, but a direct causal relationship between a specific neural circuit and repetitive behavior has not yet been established. Here we demonstrate that optogenetic activation of dopamine D1 receptor-expressing MSNs terminals in the substantia nigra pars reticulata resulted in sustained and chronic repetitive behaviors. These data show for the first time that activation of the striatonigral direct pathway is sufficient to generate motor stereotypies.

Keywords: Autistic spectrum disorder (ASD); D1-MSNs; Direct pathway; Obsessive-compulsive spectrum disorders (OCSD); Optogenetics; Repetitive behaviors; Striato-nigral pathway; Tourette syndrom.