The evolving landscape of new diagnostic tests for invasive aspergillosis in hematology patients: strengths and weaknesses

Curr Opin Infect Dis. 2017 Dec;30(6):539-544. doi: 10.1097/QCO.0000000000000408.

Abstract

Purpose of review: The diagnosis of invasive aspergillosis in hematologic patients is a complex composite of clinical preconditions and features, imaging findings, biomarker combinations from appropriate clinical samples and microbiological and/or histological findings.

Recent findings: Recent developments in the evolving landscape of diagnostic tests for invasive aspergillosis in adult hematology patients are highlighted.

Summary: Novel approaches and tools are currently under development. Focusing optimized diagnostic performance, in particular the combination of biomarkers from appropriate clinical samples, improved diagnostic performance distinctly.

Publication types

  • Review

MeSH terms

  • Biomarkers / analysis
  • Hematologic Neoplasms / complications*
  • Humans
  • Immunocompromised Host
  • Invasive Pulmonary Aspergillosis / complications*
  • Invasive Pulmonary Aspergillosis / diagnosis*
  • Invasive Pulmonary Aspergillosis / diagnostic imaging
  • Invasive Pulmonary Aspergillosis / metabolism
  • Mycological Typing Techniques
  • Radiography, Thoracic
  • Tomography, X-Ray Computed

Substances

  • Biomarkers