Peripartum Cardiomyopathy: Do Exosomes Play a Role?

Adv Exp Med Biol. 2017:998:139-149. doi: 10.1007/978-981-10-4397-0_9.

Abstract

Peripartum cardiomyopathy (PPCM) refers to irreversible cardiomyocyte damage that occurs during the last month of pregnancy, or within 5 months after giving birth. It is characterized by systolic heart failure. This life-threatening condition is relatively uncommon, but the incidence has been climbing up. Because of its high mortality, it is crucial for physicians to have high suspicious for the disease. Studies have been done to search into specific lab test and treatment for PPCM. Therapies like anti-viral, anti-inflammatory and immunosuppression regimen have been explored. New regimen like exosomes has also been explored and revealed promising effects.

Keywords: Exosome; Peripartum cardiomyopathy.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Cardiomyopathies / epidemiology
  • Cardiomyopathies / metabolism*
  • Cardiomyopathies / pathology
  • Cardiomyopathies / therapy
  • Exosomes / metabolism*
  • Exosomes / pathology
  • Female
  • Humans
  • Myocardium / metabolism*
  • Myocardium / pathology
  • Peripartum Period / metabolism*
  • Pregnancy
  • Pregnancy Complications, Cardiovascular / epidemiology
  • Pregnancy Complications, Cardiovascular / metabolism*
  • Pregnancy Complications, Cardiovascular / pathology
  • Pregnancy Complications, Cardiovascular / therapy
  • Prognosis
  • Risk Factors
  • Signal Transduction*