Ethyl cellulose (EC) nanodispersions have been prepared through a facile procedure, a process involved the dissolution of EC into ethanol, followed by dipping it in Xanthan Gum (XG) solution (0.1%, used as anti-solvent), and then removed the ethanol. The influences of preparation conditions on the structure and properties of the EC nanodispersions were investigated. The prepared EC nanodispersion had a negative surface potential, which contributed to its stabilization. The particle size of the nanodispersions could be controlled by changing the concentration of EC. Furthermore, the EC nanodispersions had a potential application for the stabilization of oil/water Pickering emulsion. The obtained Pickering emulsions showed high stability.