A genome-wide association study of LCH identifies a variant in SMAD6 associated with susceptibility

Blood. 2017 Nov 16;130(20):2229-2232. doi: 10.1182/blood-2017-08-800565. Epub 2017 Sep 21.

Authors

Erin C Peckham-Gregory^{1

2}, Rikhia Chakraborty^{1

2}, Michael E Scheurer^{1

2}, John W Belmont^{3

4}, Harshal Abhyankar¹, Amel G Sengal¹, Brooks P Scull¹, Olive Eckstein¹, Daniel J Zinn¹, Louisa Mayer^{1

2}, Albert Shih¹, Miriam Merad⁵, D Williams Parsons^{1

2

3}, Kenneth L McClain^{1

2}, Philip J Lupo^{1

2}, Carl E Allen^{1

2}

Affiliations

¹ Texas Children's Cancer and Hematology Centers, Texas Children's Hospital, Houston, TX.
² Section of Pediatric Hematology-Oncology, Department of Pediatrics.
³ Department of Molecular and Human Genetics, and.
⁴ Children's Nutrition Research Center, Baylor College of Medicine, Houston, TX; and.
⁵ Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY.

No abstract available

Publication types

Letter
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

MeSH terms

Case-Control Studies
Family
Genetic Predisposition to Disease*
Genome-Wide Association Study / methods*
Germ-Line Mutation*
Histiocytosis, Langerhans-Cell / genetics*
Humans
Polymorphism, Single Nucleotide
Smad6 Protein / genetics*

Substances

SMAD6 protein, human
Smad6 Protein

Grants and funding