Lung cancer is becoming an increasing threat to Chinese residents and its incidence continues to rise while the treatment effect is far from satisfactory. Hence, it is essential to improve the level of early diagnosis, treatment, prognosis in lung cancer. An epigenetic trait is a stably heritable phenotype resulting from changes in a chromosome without alterations in the DNA sequence. The epigenetic studies, such as DNA methylation and histone methylation, are progressing rapidly in oncology research. A comprehensive understanding of its development status and existing problems is of great significance for the future research and the implementation of precision medicine. Herein, we aim to outline the progress of DNA methylation and histone methylation modification in lung cancer and make a prospect for the future research.
肺癌愈发成为威胁中国居民生命的恶性疾病，其发病率持续攀升而治疗效果不尽如人意，因此加强其早期诊断、治疗、预后等方面的研究至关重要。以“不依赖DNA序列改变而又可遗传的基因表达改变”为特点的表观遗传学研究近年来进展迅猛，尤其在DNA甲基化及组蛋白甲基化修饰研究方面取得了一系列具有临床应用价值的研究成果，全面认识其发展现状及存在问题对下一步的研究工作及实施精准医疗意义重大。本文旨在概述DNA甲基化及组蛋白甲基化修饰在肺癌领域的进展情况，并对今后相关方向的研究做出展望。.