A bioanalytical approach of chemical composition, bioactivity and cytotoxicity of Berteroa incana L. herb

Nat Prod Res. 2018 Dec;32(23):2791-2796. doi: 10.1080/14786419.2017.1380014. Epub 2017 Sep 21.

Abstract

Berteroa incana is a wild herb widespread in temperate zones which was practically not studied for its biological effects. Methanolic and aqueous extracts of B. incana were assessed for the content in polyphenols and the related antioxidant and antimicrobial activities and the polysaccharide extract for the content in saccharides and the associated cytostatic effect. The results obtained highlighted that the methanolic extracts of B. incana contain moderate amounts of polyphenols, the most representative been isoquercitrin 4.41 ± 0.02 mg100 g-1dry weight plant material (DW), quercetin 4.21 ± 0.05, sinapic acid 5.23 ± 0.12 and ferulic acid 5.05 ± 0.12 mg 100 g-1DW, with correlated moderate antioxidant activities (IC50 13.40 ± 0.01 μg mL-1) and absent antibacterial activity. The polysaccharide fraction showed high content in saccharides, especially in arabinose (312.22 ± 7.54 mg g-1 polysaccharide extract) and glucose (279.22 ± 5.59), and promising cytostatic effect.

Keywords: antimicrobial activity; antioxidant activity; cytotoxicity; polyphenols; saccharides.

MeSH terms

  • Anti-Bacterial Agents / analysis
  • Antioxidants / isolation & purification
  • Antioxidants / pharmacology
  • Arabinose / analysis
  • Asteraceae
  • Brassicaceae / chemistry*
  • Cytotoxins / analysis
  • Cytotoxins / chemistry
  • Cytotoxins / isolation & purification
  • Glucose / analysis
  • Plant Extracts / chemistry*
  • Plant Extracts / pharmacology
  • Plants, Medicinal / chemistry*
  • Polyphenols / analysis
  • Polyphenols / pharmacology
  • Polysaccharides / analysis
  • Polysaccharides / pharmacology

Substances

  • Anti-Bacterial Agents
  • Antioxidants
  • Cytotoxins
  • Plant Extracts
  • Polyphenols
  • Polysaccharides
  • Arabinose
  • Glucose