Differential context-specific impact of individual core promoter elements on transcriptional dynamics

Mol Biol Cell. 2017 Nov 7;28(23):3360-3370. doi: 10.1091/mbc.E17-06-0408. Epub 2017 Sep 20.

Abstract

Eukaryotic transcription occurs in bursts that vary in size and frequency, but the contribution of individual core promoter elements to transcriptional bursting is not known. Here we analyze the relative contributions to bursting of the individual core promoter elements-CCAAT, TATAA-like, Sp1BS, and Inr-of an MHC class I gene in primary B-cells during both basal and activated transcription. The TATAA-like, Sp1BS, and Inr elements all function as negative regulators of transcription, and each was found to contribute differentially to the overall bursting pattern of the promoter during basal transcription. Whereas the Sp1BS element regulates burst size, the Inr element regulates burst frequency. The TATAA-like element contributes to both. Surprisingly, each element has a distinct role in bursting during transcriptional activation by γ-interferon. The CCAAT element does not contribute significantly to the constitutive transcriptional dynamics of primary B-cells, but modulates both burst size and frequency in response to γ-interferon activation. The ability of core promoter elements to modulate transcriptional bursting individually allows combinatorial fine-tuning of the level of MHC class I gene expression in response to intrinsic and extrinsic signals.

MeSH terms

  • B-Lymphocytes
  • Gene Expression Regulation / genetics*
  • Humans
  • Interferon-gamma / metabolism
  • Promoter Regions, Genetic / genetics
  • Promoter Regions, Genetic / physiology*
  • Trans-Activators / metabolism
  • Transcription Factors / metabolism
  • Transcription, Genetic / genetics
  • Transcriptional Activation / genetics*
  • Transcriptional Activation / physiology

Substances

  • Trans-Activators
  • Transcription Factors
  • Interferon-gamma