Microfluidics is undoubtedly an influential technology that is currently revolutionizing the chemical and biological studies by replicating laboratory bench-top technology on a miniature chip-scale device. In the area of drug delivery science, microfluidics offers advantages, such as precise dosage, ideal delivery, target-precise delivery, sustainable and controlled release, multiple dosing, and slight side effects. These advantages bring significant assets to the drug delivery systems. Microfluidic technology has been progressively used for fabrication of drug carriers, direct drug delivery systems, high-throughput screening, and formulation and immobilization of drugs. This review discusses the recent technological progress, outcomes and available opportunities for the usage of microfluidics systems in drug delivery systems.