Development of a Cigarette Tobacco Filler Standard Reference Material

Anal Chem. 2017 Oct 3;89(19):10461-10467. doi: 10.1021/acs.analchem.7b02550. Epub 2017 Sep 20.

Abstract

A new tobacco filler Standard Reference Material (SRM) has been issued by the National Institute of Standards and Technology (NIST) in September 2016 with certified and reference mass fraction values for nicotine, N-nitrosonornicotine, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone, and volatiles. The constituents have been determined by multiple analytical methods with measurements at NIST and at the Centers for Disease Control and Prevention, and with confirmatory measurements by commercial laboratories. This effort highlights the development of the first SRM for reduced nicotine and reduced tobacco-specific nitrosamines with certified values for composition.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Chromatography, High Pressure Liquid / methods
  • Chromatography, High Pressure Liquid / standards
  • Freezing
  • Gas Chromatography-Mass Spectrometry / methods*
  • Gas Chromatography-Mass Spectrometry / standards
  • Nicotine / analysis
  • Nicotine / standards
  • Nitrosamines / analysis
  • Nitrosamines / standards
  • Phase Transition
  • Reference Standards
  • Tandem Mass Spectrometry / methods*
  • Tandem Mass Spectrometry / standards
  • Tobacco Products / analysis*
  • Tobacco Products / standards
  • Volatile Organic Compounds / analysis
  • Volatile Organic Compounds / standards

Substances

  • Nitrosamines
  • Volatile Organic Compounds
  • Nicotine
  • 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone
  • N'-nitrosonornicotine