Carbapenemase VCC-1-Producing Vibrio cholerae in Coastal Waters of Germany

Emerg Infect Dis. 2017 Oct;23(10):1735-1737. doi: 10.3201/eid2310.161625.

Abstract

During antimicrobial drug resistance testing for Vibrio spp. from coastal waters of Germany, we identified 4 nontoxigenic, carbapenem-resistant V. cholerae isolates. We used whole-genome sequencing to identify the carbapenemase gene blaVCC-1. In addition, a molecular survey showed that more blaVCC-1-harboring isolates are present in coastal waters of Germany.

Keywords: Europe; Germany; Vibrio cholerae; antimicrobial resistance; bacteria; carbapenem resistance; carbapenemase VCC-1; coastal water; environment; multilocus sequence typing; sequence type; whole-genome sequencing.

MeSH terms

  • Anti-Bacterial Agents / pharmacology
  • Bacterial Proteins / genetics*
  • Bacterial Proteins / metabolism
  • Carbapenems / pharmacology
  • Gene Expression
  • Genome, Bacterial*
  • Germany
  • Humans
  • Microbial Sensitivity Tests
  • Multilocus Sequence Typing
  • Seawater / microbiology*
  • Vibrio cholerae / drug effects
  • Vibrio cholerae / enzymology
  • Vibrio cholerae / genetics*
  • Vibrio cholerae / isolation & purification
  • Water Microbiology
  • beta-Lactamases / genetics*
  • beta-Lactamases / metabolism

Substances

  • Anti-Bacterial Agents
  • Bacterial Proteins
  • Carbapenems
  • beta-Lactamases
  • carbapenemase