Anti-Inflammatory and Anti-Oxidative Activities of Phenolic Compounds from Alnus sibirica Stems Fermented by Lactobacillus plantarum subsp. argentoratensis

Molecules. 2017 Sep 18;22(9):1566. doi: 10.3390/molecules22091566.

Abstract

Fermentation of Alnus sibirica (AS) stems using Lactobacillus plantarum subsp. argentoratensis was conducted and three compounds isolated from the Alnus species were identified for the first time, 7-(3,4-dihydroxyphenyl)-1-(4-hydroxyphenyl)-heptan-3-one, 1-(3,4-dihydroxyphenyl)-7-(4-hydroxyphenyl)-heptan-3-one and 4-(3,4-dihydroxyphenyl)-butan-2-one, along with 14 known compounds. The anti-oxidative and anti-inflammatory abilities of AS and fermented AS (FAS) as well as the isolated phenolic compounds from FAS were investigated. FAS showed stronger anti-oxidative and anti-inflammatory activities than non-fermented AS.

Keywords: Alnus sibirica; diarylheptanoid; fermentation.

MeSH terms

  • Alnus / chemistry*
  • Animals
  • Anti-Inflammatory Agents / chemistry*
  • Anti-Inflammatory Agents / pharmacology
  • Antioxidants / chemistry*
  • Antioxidants / pharmacology
  • Diarylheptanoids / chemistry
  • Diarylheptanoids / pharmacology
  • Fermentation
  • Humans
  • Lactobacillus plantarum*
  • Mice
  • Phenols / chemistry*
  • Phenols / pharmacology
  • Plant Extracts / chemistry
  • Plant Extracts / pharmacology
  • Plant Stems / chemistry
  • RAW 264.7 Cells

Substances

  • Anti-Inflammatory Agents
  • Antioxidants
  • Diarylheptanoids
  • Phenols
  • Plant Extracts