Colocation of the Multiresistance Gene cfr and the Fosfomycin Resistance Gene fosD on a Novel Plasmid in Staphylococcus arlettae from a Chicken Farm

Antimicrob Agents Chemother. 2017 Nov 22;61(12):e01388-17. doi: 10.1128/AAC.01388-17. Print 2017 Dec.

Abstract

The novel 63,558-bp plasmid pSA-01, which harbors nine antibiotic resistance genes, including cfr, erm(C), tet(L), erm(T), aadD, fosD, fexB, aacA-aphD, and erm(B), was characterized in Staphylococcus arlettae strain SA-01, isolated from a chicken farm in China. The colocation of cfr and fosD genes was detected for the first time in an S. arlettae plasmid. The detection of two IS431-mediated circular forms containing resistance genes in SA-01 suggested that IS431 may facilitate dissemination of antibiotic resistance genes.

Keywords: IS431; Staphylococcus arlettae; cfr; circular form; fosD.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Anti-Bacterial Agents / pharmacology*
  • Bacterial Proteins / genetics*
  • Bacterial Proteins / metabolism
  • Chickens
  • China / epidemiology
  • Drug Resistance, Multiple, Bacterial / genetics*
  • Farms
  • Fosfomycin / pharmacology*
  • High-Throughput Nucleotide Sequencing
  • Microbial Sensitivity Tests
  • Plasmids / chemistry*
  • Plasmids / metabolism
  • Poultry Diseases / epidemiology
  • Poultry Diseases / microbiology
  • Staphylococcal Infections / epidemiology
  • Staphylococcal Infections / microbiology
  • Staphylococcal Infections / veterinary*
  • Staphylococcus / drug effects
  • Staphylococcus / genetics*
  • Staphylococcus / isolation & purification
  • Staphylococcus / metabolism

Substances

  • Anti-Bacterial Agents
  • Bacterial Proteins
  • Fosfomycin