miR-206/133b Cluster: A Weapon against Lung Cancer?

Jing-Yu Pan; Cheng-Cao Sun; Zhuo-Yue Bi; Zhen-Long Chen; Shu-Jun Li; Qing-Qun Li; Yu-Xuan Wang; Yong-Yi Bi; De-Jia Li

doi:10.1016/j.omtn.2017.06.002

miR-206/133b Cluster: A Weapon against Lung Cancer?

Mol Ther Nucleic Acids. 2017 Sep 15:8:442-449. doi: 10.1016/j.omtn.2017.06.002. Epub 2017 Jun 7.

Authors

Jing-Yu Pan¹, Cheng-Cao Sun², Zhuo-Yue Bi³, Zhen-Long Chen⁴, Shu-Jun Li⁵, Qing-Qun Li¹, Yu-Xuan Wang¹, Yong-Yi Bi¹, De-Jia Li⁶

Affiliations

¹ Department of Occupational and Environmental Health, School of Public Health, Wuhan University, Wuhan 430071 Hubei, P.R. China.
² Department of Occupational and Environmental Health, School of Public Health, Wuhan University, Wuhan 430071 Hubei, P.R. China. Electronic address: chengcaosun@whu.edu.cn.
³ Hubei Provincial Key Laboratory for Applied Toxicology (Hubei Provincial Academy for Preventive Medicine), Wuhan 430079 Hubei, P.R. China.
⁴ Wuhan Hospital for the Prevention and Treatment of Occupational Diseases, Wuhan 430022 Hubei, P.R. China.
⁵ Department of Occupational and Environmental Health, School of Public Health, Wuhan University, Wuhan 430071 Hubei, P.R. China; Wuhan Hospital for the Prevention and Treatment of Occupational Diseases, Wuhan 430022 Hubei, P.R. China.
⁶ Department of Occupational and Environmental Health, School of Public Health, Wuhan University, Wuhan 430071 Hubei, P.R. China. Electronic address: lodjlwhu@sina.com.

Abstract

Lung cancer is a deadly disease that ends numerous lives around the world. MicroRNAs (miRNAs) are a group of non-coding RNAs involved in a variety of biological processes, such as cell growth, organ development, and tumorigenesis. The miR-206/133b cluster is located on the human chromosome 6p12.2, which is essential for growth and rebuilding of skeletal muscle. The miR-206/133b cluster has been verified to be dysregulated and plays a crucial role in lung cancer. miR-206 and miR-133b participate in lung tumor cell apoptosis, proliferation, migration, invasion, angiogenesis, drug resistance, and cancer treatment. The mechanisms are sophisticated, involving various target genes and molecular pathways, such as MET, EGFR, and the STAT3/HIF-1α/VEGF signal pathway. Hence, in this review, we summarize the role and potential mechanisms of the miR-206/133b cluster in lung cancer.

Keywords: lung cancer; miR-133b; miR-206; miR-206/133b cluster.

Publication types

Review