Development of poly (1, 8-octanediol citrate)/chitosan blend films for tissue engineering applications

Ehsan Zeimaran; Sara Pourshahrestani; Belinda Pingguan-Murphy; Daniel Kong; Sangeetha Vasudevaraj Naveen; Tunku Kamarul; Nahrizul Adib Kadri

doi:10.1016/j.carbpol.2017.08.038

Development of poly (1, 8-octanediol citrate)/chitosan blend films for tissue engineering applications

Carbohydr Polym. 2017 Nov 1:175:618-627. doi: 10.1016/j.carbpol.2017.08.038. Epub 2017 Aug 12.

Authors

Ehsan Zeimaran¹, Sara Pourshahrestani², Belinda Pingguan-Murphy², Daniel Kong³, Sangeetha Vasudevaraj Naveen⁴, Tunku Kamarul⁴, Nahrizul Adib Kadri⁵

Affiliations

¹ Department of Biomedical Engineering, Faculty of Engineering, University of Malaya, 50603 Kuala Lumpur, Malaysia; School of Engineering, Monash University, 47500 Bandar Sunway, Selangor, Malaysia. Electronic address: ehsanzeimaran@gmail.com.
² Department of Biomedical Engineering, Faculty of Engineering, University of Malaya, 50603 Kuala Lumpur, Malaysia.
³ School of Engineering, Monash University, 47500 Bandar Sunway, Selangor, Malaysia.
⁴ Tissue Engineering Group (TEG), National Orthopaedic Centre of Excellence in Research and Learning (NOCERAL), Department of Orthopaedic Surgery, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, Malaysia.
⁵ Department of Biomedical Engineering, Faculty of Engineering, University of Malaya, 50603 Kuala Lumpur, Malaysia. Electronic address: nahrizuladib@um.edu.my.

PMID: 28917909
DOI: 10.1016/j.carbpol.2017.08.038

Abstract

Blends of poly (1, 8-octanediol citrate) (POC) and chitosan (CS) were prepared through solution casting technique. Films with different component fractions (POC/CS: 100/0, 90/10, 80/20, 70/30, 60/40, and 0/100) were successfully prepared and characterized for their mechanical, thermal, structural and morphological properties as well as biocompatibility. The incorporation of CS to POC significantly increased tensile strength and elastic modulus and presented limited influences on pH variation which is important to the biocompatibility of biomaterial implants. The assessment of surface topography indicated that blending could enhance and control the surface roughness of the pure films. POC/CS blends well-supported human dermal fibroblast cells attachment and proliferation, and thus can be used for a range of tissue engineering applications.

Keywords: 8-octanediol citrate); Biocompatible; Blend films; Chitosan; Poly (1,; Tissue engineering.

MeSH terms

Biocompatible Materials*
Cells, Cultured
Chitosan / chemistry*
Citrates / chemistry*
Fibroblasts / cytology
Humans
Materials Testing
Tissue Engineering*

Substances

Biocompatible Materials
Citrates
Chitosan