Neurosurgical Applications of High-Intensity Focused Ultrasound with Magnetic Resonance Thermometry

Rivka R Colen; Iman Sahnoune; Jeffrey S Weinberg

doi:10.1016/j.nec.2017.05.008

Neurosurgical Applications of High-Intensity Focused Ultrasound with Magnetic Resonance Thermometry

Neurosurg Clin N Am. 2017 Oct;28(4):559-567. doi: 10.1016/j.nec.2017.05.008.

Authors

Rivka R Colen¹, Iman Sahnoune², Jeffrey S Weinberg³

Affiliations

¹ Department of Cancer Systems Imaging and Diagnostic Radiology, The University of Texas MD Anderson Cancer Center, 1881 East Road, 3SCR4.3600, Unit 1907, Houston, TX 77054-1907, USA.
² Department of Cancer Systems Imaging, MD Anderson UTHealth Graduate School of Biomedical Sciences, The University of Texas MD Anderson Cancer Center, 1881 East Road, 3SCR4.3600, Unit 1907, Houston, TX 77054-1907, USA.
³ Department of Neurosurgery, The University of Texas MD Anderson Cancer Center, PO Box 301402-442, Houston, TX 77230-1402, USA. Electronic address: jweinberg@mdanderson.org.

PMID: 28917284
DOI: 10.1016/j.nec.2017.05.008

Abstract

Magnetic resonance guided focused ultrasound surgery (MRgFUS) has potential noninvasive effects on targeted tissue. MRgFUS integrates MRI and focused ultrasound surgery (FUS) into a single platform. MRI enables visualization of the target tissue and monitors ultrasound-induced effects in near real-time during FUS treatment. MRgFUS may serve as an adjunct or replace invasive surgery and radiotherapy for specific conditions. Its thermal effects ablate tumors in locations involved in movement disorders and essential tremors. Its nonthermal effects increase blood-brain barrier permeability to enhance delivery of therapeutics and other molecules.

Keywords: Brain; Focused ultrasound; Glioma; MRgFUS; Magnetic resonance–guided focused ultrasound surgery.

Publication types

Review

MeSH terms

Brain Neoplasms / therapy
Essential Tremor / diagnostic imaging*
Essential Tremor / therapy*
Extracorporeal Shockwave Therapy / methods*
Humans
Hyperthermia, Induced / methods*
Magnetic Resonance Imaging, Interventional / methods*