Valve Interstitial Cells: The Key to Understanding the Pathophysiology of Heart Valve Calcification

Arkady Rutkovskiy; Anna Malashicheva; Gareth Sullivan; Maria Bogdanova; Anna Kostareva; Kåre-Olav Stensløkken; Arnt Fiane; Jarle Vaage

doi:10.1161/JAHA.117.006339

Valve Interstitial Cells: The Key to Understanding the Pathophysiology of Heart Valve Calcification

J Am Heart Assoc. 2017 Sep 14;6(9):e006339. doi: 10.1161/JAHA.117.006339.

Authors

Arkady Rutkovskiy^{1

2

3

4

5}, Anna Malashicheva^{6

5}, Gareth Sullivan^{7

8

9

10}, Maria Bogdanova¹¹, Anna Kostareva^{6

5}, Kåre-Olav Stensløkken^{11

2}, Arnt Fiane^{12

13}, Jarle Vaage^{12

3

5}

Affiliations

¹ Division of Physiology, Department of Molecular Medicine, Institute of Basic Medical Sciences, University of Oslo, Norway arkady.rutkovskiy@medisin.uio.no.
² Centre for Heart Failure Research, University of Oslo, Norway.
³ Department of Emergency Medicine and Intensive Care, Oslo University Hospital, Oslo, Norway.
⁴ Division of Medicine, Akershus University Hospital, Lørenskog, Norway.
⁵ ITMO University, St. Petersburg, Russia.
⁶ Almazov National Medical Research Centre, St. Petersburg, Russia.
⁷ Division of Biochemistry, Department of Molecular Medicine, Institute of Basic Medical Sciences, University of Oslo, Norway.
⁸ Hybrid Technology Hub-Centre of Excellence, Institute of Basic Medical Sciences, University of Oslo, Norway.
⁹ Institute of Immunology, Oslo University Hospital, Oslo, Norway.
¹⁰ Norwegian Center for Stem Cell Research, Oslo, Norway.
¹¹ Division of Physiology, Department of Molecular Medicine, Institute of Basic Medical Sciences, University of Oslo, Norway.
¹² Institute of Clinical Medicine, University of Oslo, Norway.
¹³ Department of Cardiothoracic Surgery, Oslo University Hospital, Oslo, Norway.

No abstract available

Keywords: aortic stenosis; ectopic bone formation; myofibroblasts; valve endothelial cells; valve interstitial cells.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
Aortic Valve / metabolism
Aortic Valve / pathology*
Aortic Valve / physiopathology
Aortic Valve Stenosis / metabolism
Aortic Valve Stenosis / pathology*
Aortic Valve Stenosis / physiopathology
Calcinosis / metabolism
Calcinosis / pathology*
Calcinosis / physiopathology
Cell Differentiation
Cell Separation / methods
Cells, Cultured
Fibroblasts / metabolism
Fibroblasts / pathology*
Hemodynamics*
Humans
Inflammation Mediators / metabolism
MicroRNAs / genetics
MicroRNAs / metabolism
Myofibroblasts / metabolism
Myofibroblasts / pathology
Osteoblasts / metabolism
Osteoblasts / pathology*
Osteogenesis
Phenotype
Signal Transduction

Substances

Inflammation Mediators
MicroRNAs

Supplementary concepts

Aortic Valve, Calcification of