Novel Agents and Drug Targets to Meet the Challenges of Resistant Fungi

Abstract

The emergence of drug-resistant fungi poses a major threat to human health. Despite advances in preventive, diagnostic, and therapeutic interventions, resistant fungal infections continue to cause significant morbidity and mortality in patients with compromised immunity, underscoring the urgent need for new antifungal agents. In this article, we review the challenges associated with identifying broad-spectrum antifungal drugs and highlight novel targets that could enhance the armamentarium of agents available to treat drug-resistant invasive fungal infections.

Keywords: E1210; chelator; dihydroorotate dehydrogenase; epigenetic; glycosphingolipids; glycosylphosphatidylinositol; transcription factors.