Synthesis of New Bis-Spiropyrazoles as Antitumor Agents under Ultrasound Irradiation

Naglaa A Abdel Hafez; Huwaida M E Hassaneen; Thoraya A Farghaly; Sayed M Riyadh; Heba S A Elzahabi

doi:10.2174/1389557517666170912170027

Synthesis of New Bis-Spiropyrazoles as Antitumor Agents under Ultrasound Irradiation

Mini Rev Med Chem. 2018;18(7):631-637. doi: 10.2174/1389557517666170912170027.

Authors

Naglaa A Abdel Hafez¹, Huwaida M E Hassaneen², Thoraya A Farghaly^{2

3}, Sayed M Riyadh^{2

4}, Heba S A Elzahabi⁵

Affiliations

¹ Department of Applied Organic Chemistry, National Research Center, Dokki, Cairo, Egypt.
² Department of Chemistry, Faculty of Science, Cairo University, Giza 12613, Egypt.
³ Department of Chemistry, Faculty of Applied Science, Umm Al-Qura University, Makkah Almukkarramah, Saudi Arabia.
⁴ Department of Chemistry, Faculty of Science, Taibah University, AlmadinahAlmunawrah, 30002, Saudi Arabia.
⁵ Department of Pharmaceutical Chemistry, Faculty of Pharmacy (Girls), Al Azhar University, Cairo, 11754, Egypt.

PMID: 28901853
DOI: 10.2174/1389557517666170912170027

Abstract

Objective and background: Hydrazonoyl halides were used as precursors for the synthesis of a new series of bis-spiropyrazoles via reaction with 3,5-diarylidene-piperidone derivatives under ultrasound irradiation. The products were secluded in good yield after short reaction periods.

Conclusion: The anticancer activity of bis-spiropyrazoles against HepG2 (hepatic cancer), A549 (lung cancer) and CaCo2 (colon cancer) cell lines was screened. Three tested compounds 4b, 4c and 4f showed promising activity.

Keywords: 3; 5-diarylidene-piperidones; Antitumor activity; Bis-spiropyrazoles; hydrazonoyl halides; spiropiperidinecarbinols; ultrasound irradiation..

MeSH terms

Antineoplastic Agents / chemical synthesis
Antineoplastic Agents / chemistry
Antineoplastic Agents / pharmacology*
Caco-2 Cells
Cell Line, Tumor
Cell Proliferation / drug effects
Cell Survival / drug effects
Dose-Response Relationship, Drug
Drug Screening Assays, Antitumor
Hep G2 Cells
Humans
Molecular Structure
Pyrazoles / chemical synthesis
Pyrazoles / chemistry
Pyrazoles / pharmacology*
Spiro Compounds / chemical synthesis
Spiro Compounds / chemistry
Spiro Compounds / pharmacology*
Structure-Activity Relationship
Ultrasonic Waves*

Substances

Antineoplastic Agents
Pyrazoles
Spiro Compounds