Intramolecular Pd-Catalyzed Anomeric C(sp3)-H Activation of Glycosyl Carboxamides

Org Lett. 2017 Oct 6;19(19):5038-5041. doi: 10.1021/acs.orglett.7b02170. Epub 2017 Sep 13.

Abstract

An expedient method for the synthesis of fused glycosylquinolin-2-ones and glycosylspirooxindoles through an unprecedented intramolecular Pd-catalyzed anomeric C-H activation of the sugar moiety of 2-bromophenyl glycosylcarboxamides is reported. The scope of the reaction is broad and tolerates a wide range of functional groups.

Publication types

  • Research Support, Non-U.S. Gov't