State of diagnosing infectious pathogens using colloidal nanomaterials

Jisung Kim; Mohamed A Abdou Mohamed; Kyryl Zagorovsky; Warren C W Chan

doi:10.1016/j.biomaterials.2017.08.013

State of diagnosing infectious pathogens using colloidal nanomaterials

Biomaterials. 2017 Nov:146:97-114. doi: 10.1016/j.biomaterials.2017.08.013. Epub 2017 Aug 17.

Authors

Jisung Kim¹, Mohamed A Abdou Mohamed², Kyryl Zagorovsky³, Warren C W Chan⁴

Affiliations

¹ Institute of Biomaterials and Biomedical Engineering, University of Toronto, Toronto, Ontario M5S 3G9, Canada; Terrence Donnelly Centre for Cellular and Bimolecular Research, University of Toronto, Toronto, Ontario M5S 3E1, Canada; Centre for Global Engineering, University of Toronto, Toronto, Ontario M5S 1A4, Canada.
² Institute of Biomaterials and Biomedical Engineering, University of Toronto, Toronto, Ontario M5S 3G9, Canada; Terrence Donnelly Centre for Cellular and Bimolecular Research, University of Toronto, Toronto, Ontario M5S 3E1, Canada; Botany and Microbiology Department, Faculty of Science, Zagazig University, Egypt.
³ Institute of Biomaterials and Biomedical Engineering, University of Toronto, Toronto, Ontario M5S 3G9, Canada; Terrence Donnelly Centre for Cellular and Bimolecular Research, University of Toronto, Toronto, Ontario M5S 3E1, Canada.
⁴ Institute of Biomaterials and Biomedical Engineering, University of Toronto, Toronto, Ontario M5S 3G9, Canada; Terrence Donnelly Centre for Cellular and Bimolecular Research, University of Toronto, Toronto, Ontario M5S 3E1, Canada; Department of Chemistry, University of Toronto, Toronto, Ontario M5S 3H6, Canada; Department of Chemical Engineering, University of Toronto, Toronto, Ontario M5S 3E5, Canada; Department of Materials Science and Engineering, University of Toronto, Toronto, Ontario M5S 3E4, Canada. Electronic address: warren.chan@utoronto.ca.

Abstract

Infectious diseases are a major global threat that accounts for one of the leading causes of global mortality and morbidity. Prompt diagnosis is a crucial first step in the management of infectious threats, which aims to quarantine infected patients to avoid contacts with healthy individuals and deliver effective treatments prior to further spread of diseases. This review article discusses current advances of diagnostic systems using colloidal nanomaterials (e.g., gold nanoparticles, quantum dots, magnetic nanoparticles) for identifying and differentiating infectious pathogens. The challenges involved in the clinical translation of these emerging nanotechnology based diagnostic devices will also be discussed.

Keywords: Clinical translation; Diagnostics; Nanomaterials; Nanotechnology; Point of care.

Publication types

Review

MeSH terms

Gold / chemistry
Humans
Metal Nanoparticles / chemistry*
Nanostructures / chemistry*
Nanotechnology / methods*
Quantum Dots

Substances

Gold