A DNA Crosslinker Collects Mitotic Chromosomes

Mingxuan Sun; Rebecca Heald

doi:10.1016/j.devcel.2017.08.010

A DNA Crosslinker Collects Mitotic Chromosomes

Dev Cell. 2017 Sep 11;42(5):440-442. doi: 10.1016/j.devcel.2017.08.010.

Authors

Mingxuan Sun¹, Rebecca Heald²

Affiliations

¹ Molecular and Cell Biology Department, University of California, Berkeley, Berkeley, CA 94720-3200, USA.
² Molecular and Cell Biology Department, University of California, Berkeley, Berkeley, CA 94720-3200, USA. Electronic address: bheald@berkeley.edu.

PMID: 28898675
DOI: 10.1016/j.devcel.2017.08.010

Abstract

Incorporating each set of daughter chromosomes into a single nucleus at the end of mitosis is essential for genome stability. In a recent Cell paper, Samwer et al. (2017) show that by non-covalently crosslinking DNA, BAF promotes chromosome coalescence, preventing nuclear membranes from enwrapping individual chromosomes to form micronuclei.

Publication types

Comment

MeSH terms

Cell Nucleus
Chromosomes*
DNA
Humans
Mitosis*
Nuclear Envelope

Substances

DNA