AURKA inhibition mimics BRCAness

Aging (Albany NY). 2017 Sep 11;9(9):1945-1946. doi: 10.18632/aging.101291.

Authors

Jeff Hirst¹, Andrew K Godwin^{1

2}

Affiliations

¹ Department of Pathology and Laboratory Medicine, University of Kansas Medical Center, Kansas City, KS 66201, USA.
² University of Kansas Cancer Center, University of Kansas Medical Center, Kansas City, KS 66201, USA.

No abstract available

Keywords: Aurora A kinase; BRCAness; PARP inhibition; non-homologous end joining; synthetic lethality.

Publication types

Editorial

MeSH terms

Animals
Aurora Kinase A / biosynthesis
Aurora Kinase A / genetics*
BRCA2 Protein / biosynthesis
BRCA2 Protein / genetics
DNA Breaks, Double-Stranded
DNA End-Joining Repair / genetics
DNA Repair
Humans
Poly(ADP-ribose) Polymerase Inhibitors / pharmacology

Substances

BRCA2 Protein
BRCA2 protein, human
Poly(ADP-ribose) Polymerase Inhibitors
AURKA protein, human
Aurora Kinase A