The Role of Vitamin D in Thyroid Diseases

Int J Mol Sci. 2017 Sep 12;18(9):1949. doi: 10.3390/ijms18091949.

Abstract

The main role of vitamin D is regulating bone metabolism and calcium and phosphorus homeostasis. Over the past few decades, the importance of vitamin D in non-skeletal actions has been studied, including the role of vitamin D in autoimmune diseases, metabolic syndromes, cardiovascular disease, cancers, and all-cause mortality. Recent evidence has demonstrated an association between low vitamin D status and autoimmune thyroid diseases such as Hashimoto's thyroiditis and Graves' disease, and impaired vitamin D signaling has been reported in thyroid cancers. This review will focus on recent data on the possible role of vitamin D in thyroid diseases, including autoimmune thyroid diseases and thyroid cancers.

Keywords: Graves’ disease; Hashimoto’s thyroiditis; autoimmune thyroid disease; thyroid cancer; vitamin D.

Publication types

  • Review

MeSH terms

  • Animals
  • Autoimmune Diseases
  • Dietary Supplements
  • Graves Disease / drug therapy
  • Hashimoto Disease / drug therapy
  • Humans
  • Thyroid Diseases / drug therapy
  • Thyroid Gland / drug effects
  • Thyroid Gland / physiology
  • Thyroid Neoplasms / drug therapy*
  • Thyroiditis, Autoimmune / drug therapy*
  • Vitamin D / administration & dosage
  • Vitamin D / physiology*
  • Vitamin D / therapeutic use
  • Vitamin D Deficiency / drug therapy
  • Vitamins / therapeutic use

Substances

  • Vitamins
  • Vitamin D