Gene Therapy Approaches to Human Immunodeficiency Virus and Other Infectious Diseases

Geoffrey L Rogers; Paula M Cannon

doi:10.1016/j.hoc.2017.06.008

Gene Therapy Approaches to Human Immunodeficiency Virus and Other Infectious Diseases

Hematol Oncol Clin North Am. 2017 Oct;31(5):883-895. doi: 10.1016/j.hoc.2017.06.008.

Authors

Geoffrey L Rogers¹, Paula M Cannon²

Affiliations

¹ Department of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern California, 2011 Zonal Avenue, HMR 413A, Los Angeles, CA 90033, USA.
² Department of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern California, 2011 Zonal Avenue, HMR 413A, Los Angeles, CA 90033, USA. Electronic address: pcannon@usc.edu.

PMID: 28895854
DOI: 10.1016/j.hoc.2017.06.008

Abstract

Advances in gene therapy technologies, particularly in gene editing, are suggesting new avenues for the treatment of human immunodeficiency virus and other infectious diseases. This article outlines recent developments in antiviral gene therapies, including those based on the disruption of entry receptors or that target viral genomes using targeted nucleases, such as the CRISPR/Cas9 system. In addition, new ways to express circulating antiviral factors, such as antibodies, and approaches to harness and engineer the immune system to provide an antiviral effect that is not naturally achieved are described.

Keywords: AAV; Cas9; Gene editing; Gene therapy; HIV; Targeted nuclease.

Publication types

Review

MeSH terms

CRISPR-Cas Systems
Communicable Diseases / therapy*
Disease Resistance / genetics
Gene Editing
Gene Expression
Gene Targeting
Genetic Engineering
Genetic Therapy* / adverse effects
Genetic Therapy* / methods
Genetic Vectors / genetics
Genome, Viral
HIV / genetics*
HIV Infections / therapy*
HIV Infections / virology*
Humans
Immunomodulation / genetics
Receptors, HIV / genetics
Receptors, HIV / metabolism
Transgenes

Substances

Receptors, HIV